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| Egypt. J.Agric. Res. 79 (4) , 2001
Studies on the effect of different preservatives on the quality control of Antitetanic Serum
Fayka Kamal 1 , S.M. Shafey 2 , M.M.Awad 1 and A. El-Sayed 1
Veterinary Serum and Vaccine Research Institute,Agricural Research Centre,
Ministry of Agricultur, Abbassia, Cairo, Egypt.
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The effects of different preservatives on the keeping quality of antitetanic serum were investigated. The following preservatives were added cresol 0.3% cresol 0.4% phenol 0.5% phenol 0.25% phenol0.5% and merthiolate 1:10.000, merthiolate 1:5000, sodum azide1:10.000, sodium azide 1:8000, sodum azide1:5000.Sterility test, total protein, physical appearance, pH values, safety and potency test were studied on each product after one year of storage.
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In this study, it is proved that the best quality was seen in the antitetanic serum with cresol 0.4% and with sodium azide 1:5000.Both products were clear in appearance, completely sterile from aerobic,anaerobic bactria, fungus and mycoplasma.
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They were potent and safe when injected in horses. while,antitetanic serum with phenol 0.5% although it was sterile, potent and safe for injection, it gave turbidity on storage.
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