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| J. Egypt. Vet. Med . Assoo.63, . No5: 107 - 118, (2003).
Evaluation of the Immune response of Sheep Vaccinated with Aninactivated
Trivalent Vaccine aganist Rift Valley Fever, Rabies and Pasteurella Multocida infection
Eman, M.S; Hala, A.Fadl and Khodier, M.H.
Vet. Ser. Vac. Res. Inst.Abbassia, CairoP.B.131
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There is attcntion today to combined vaccines where they have a non-neglectable economic valuc. The present work could be considered a successful trial through which an inactivated trivalent vaccine was prepared a gainst Rift Valley Fever (RVF) virus; Rabies virus and pasteurella multocida (PM) using binary ehyleneimine (BEI) as anctivator for the three agents and aihydraget as adjuvant.
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According to the world quality control measures, this vaccine was found to be free from foreign contaminants, safe and immunogenoc as it was obtained from the results of safety and potency in mice, indirect hemagglutination test, test of the National Instiute of Health (NIH), passive mice protcction test, serum neutralizaation test (SNT) and ELISA.
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All vaccinated sheep did not show any signe of illness and exhibited good levels of specific humeral antibodies against each of the used antigens without any antagonizing effect of any of them against the other on the immune response of vaccinated animals. So, it could be concluded that the inactivated trivalent vaccine can be used effectively in vaccination of sheep against the three diseases.
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