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| Bine Suef Vet.Med.. (2005)
Preparation and evaluation of combined inactivated vaccine containing rota, corona viruses,
Escherichia coli bacterin and clostridium perfringens type C toxoid (Entero-4)
A.M. Daoud, R.A. Diab, S.M. Aboul Saoud S.M. Zeidan, F.F Zaki
Veterinary Serum and Vaccine Research Institute,
Abbassia, Cairo , Egypt.
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A conclusive study was conducted for preparation and evaluation of combined inactivated entero-4 vaccine containing bovine rotavirus (BRV), bovine coronavirus (BCV) . E.coli k 99 and toxoid of C. perfringens type “ C”.
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Laboratory and field evaluations were conducted on laboratory animals, calves and late pregnant cows with monitoring the activs and passitve antibodies in vaccinated cows and their offspring respectively. Laboratory evaluation proved purity safety and bigh efficacy of the vaccine without interference between different vaccine ingredients.
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Field evaluation gave satisfactory results when pregnant cows vaccinated at the stage of pregnancy with high neutralizing antibody titers against BRV, BCV and C. perfringens as well as high E. coli agglutining titers Maternal immunity passively protected offspring during the critical period of age and remained protected till the end of sampling time (30 th day post parturition).
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