..::Veterinary Serum and Vaccine Research Institute::..

Small Ruminant Research 45 (2002) 185-192

Immune response of sheep to foot and mouth disease vaccines containing different adjuvants

W. Deghaidy, A. Dauod, A. El-Molla

Veterinary Serum and Vaccine Research Institute,
Abbassia, Cairo , Egypt.

Summary

	This study evaluated the immunogenicity and immune duration of the locally produced inactivated foot and mouth disease (FMD) vaccine . currently used in Egypt as the main control of the disease.

	Three batches of FMD vaccines inactivated with binary ethyleneimine were prepared; two double oil emulsion (DOE) lots with either Arlacel A or spane 80 as emulsifier and a 30 % alhydragel vaccine. Evaluation and testing of FMD vaccine containing different adjuvants for safety.

	Sterility, and potency were carrid out. Guinea pig protective dose 50 (GPPD 50 ) was determind for each batch separately. The evaluation of three different types of vaccines in sheep revaled that the DOE- FMD vaccine using the new emulsifer spane 80 showed much higher antibody titers and longer duration of immunity than the other two vaccine prepartions.